Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
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• Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.
Locations
Other Locations
Brazil
National Institute of Cardiology
RECRUITING
Rio De Janeiro
Contact Information
Primary
EDUARDO TIBIRICA, MD, PhD
etibi@uol.com.br
+55-21-99914-6075
Time Frame
Start Date: 2023-11-01
Estimated Completion Date: 2025-12
Participants
Target number of participants: 50
Treatments
Placebo_comparator: Placebo
The placebo group will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Active_comparator: Beetroot extract
Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
Related Therapeutic Areas
Sponsors
Leads: National Institute of Cardiology, Laranjeiras, Brazil